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Skull Switch is an item found in New Super Mario Bros. in the castle fights against Bowser in World 1, against Dry Bowser, and at the final boss battle against him and Bowser Jr. Like the original Super Mario Bros., Mario must avoid the attacks of Bowser to go to the Skull Switch to defeat Bowser. When Mario gets on the platform with the switch, Bowser tries to push him back on his area.

This item is a replacement for the axe in Super Mario Bros. and sooner gets replaced with the ! Switch in New Super Mario Bros. Wii.